CRISPR-Pass: Gene Rescue of Nonsense Mutations Using Adenine Base Editors

A nonsense mutation is a substitutive mutation in a DNA sequence that causes a premature termination during translation and produces stalled proteins, resulting in dysfunction of a gene. Although it usually induces severe genetic disorders, there are no definite methods for inducing read through of...

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Detalles Bibliográficos
Autores principales: Lee, Choongil, Hyun Jo, Dong, Hwang, Gue-Ho, Yu, Jihyeon, Kim, Jin Hyoung, Park, Se-eun, Kim, Jin-Soo, Kim, Jeong Hun, Bae, Sangsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698196/
https://www.ncbi.nlm.nih.gov/pubmed/31164261
http://dx.doi.org/10.1016/j.ymthe.2019.05.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698196/
https://www.ncbi.nlm.nih.gov/pubmed/31164261
http://dx.doi.org/10.1016/j.ymthe.2019.05.013

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