The Hedgehog signal transducer Smoothened and microRNA-326: pathogenesis and regulation of drug resistance in pediatric B-cell acute lymphoblastic leukemia

PURPOSE: Multidrug resistance (MDR) and the subsequent disease relapse are the major causes of childhood acute lymphoblastic leukemia (ALL) related death. The Hedgehog (Hh) signaling pathway can contribute to cancer MDR. In the current study, Smoothened (Smo) was selected as the experimental target...

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Detalles Bibliográficos
Autores principales: Sheybani, Zahra, Rahgozar, Soheila, Ghodousi, Elaheh Sadat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698603/
https://www.ncbi.nlm.nih.gov/pubmed/31616178
http://dx.doi.org/10.2147/CMAR.S214405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698603/
https://www.ncbi.nlm.nih.gov/pubmed/31616178
http://dx.doi.org/10.2147/CMAR.S214405

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