DNMT3B shapes the mCA landscape and regulates mCG for promoter bivalency in human embryonic stem cells

DNMT3B is known as a de novo DNA methyltransferase. However, its preferential target sites for DNA methylation are largely unknown. Our analysis on ChIP-seq experiment in human embryonic stem cells (hESC) revealed that DNMT3B, mCA and H3K36me3 share the same genomic distribution profile. Deletion of...

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Detalles Bibliográficos
Autores principales: Tan, Hong Kee, Wu, Chan-Shuo, Li, Jia, Tan, Zi Hui, Hoffman, Jordan R, Fry, Christopher J, Yang, Henry, Di Ruscio, Annalisa, Tenen, Daniel G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698669/
https://www.ncbi.nlm.nih.gov/pubmed/31219573
http://dx.doi.org/10.1093/nar/gkz520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698669/
https://www.ncbi.nlm.nih.gov/pubmed/31219573
http://dx.doi.org/10.1093/nar/gkz520

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