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Evaluation of antiseizure drug efficacy and tolerability in the rat lamotrigine‐resistant amygdala kindling model

OBJECTIVE: The lamotrigine‐resistant amygdala kindling model uses repeated administration of a low dose of lamotrigine during the kindling process to produce resistance to lamotrigine, which also extends to some other antiseizure drugs (ASDs). This model of pharmacoresistant epilepsy has been incorp...

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Detalles Bibliográficos
Autores principales: Metcalf, Cameron S., Huff, Jennifer, Thomson, Kyle E., Johnson, Kristina, Edwards, Sharon F., Wilcox, Karen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698678/
https://www.ncbi.nlm.nih.gov/pubmed/31440726
http://dx.doi.org/10.1002/epi4.12354