Stability of an RNA•DNA–DNA triple helix depends on base triplet composition and length of the RNA third strand

Recent studies suggest noncoding RNAs interact with genomic DNA, forming an RNA•DNA–DNA triple helix that regulates gene expression. However, base triplet composition of pyrimidine motif RNA•DNA–DNA triple helices is not well understood beyond the canonical U•A–T and C•G–C base triplets. Using nativ...

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Detalles Bibliográficos
Autores principales: Kunkler, Charlotte N, Hulewicz, Jacob P, Hickman, Sarah C, Wang, Matthew C, McCown, Phillip J, Brown, Jessica A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698731/
https://www.ncbi.nlm.nih.gov/pubmed/31265072
http://dx.doi.org/10.1093/nar/gkz573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698731/
https://www.ncbi.nlm.nih.gov/pubmed/31265072
http://dx.doi.org/10.1093/nar/gkz573

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