Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA

The potent antiretroviral protein APOBEC3G (A3G) specifically targets and deaminates deoxycytidine nucleotides, generating deoxyuridine, in single stranded DNA (ssDNA) intermediates produced during HIV replication. A non-catalytic domain in A3G binds strongly to RNA, an interaction crucial for recru...

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Detalles Bibliográficos
Autores principales: Solomon, William C, Myint, Wazo, Hou, Shurong, Kanai, Tapan, Tripathi, Rashmi, Kurt Yilmaz, Nese, Schiffer, Celia A, Matsuo, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698744/
https://www.ncbi.nlm.nih.gov/pubmed/31424549
http://dx.doi.org/10.1093/nar/gkz550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698744/
https://www.ncbi.nlm.nih.gov/pubmed/31424549
http://dx.doi.org/10.1093/nar/gkz550

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