Cargando…

Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA

The potent antiretroviral protein APOBEC3G (A3G) specifically targets and deaminates deoxycytidine nucleotides, generating deoxyuridine, in single stranded DNA (ssDNA) intermediates produced during HIV replication. A non-catalytic domain in A3G binds strongly to RNA, an interaction crucial for recru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Solomon, William C, Myint, Wazo, Hou, Shurong, Kanai, Tapan, Tripathi, Rashmi, Kurt Yilmaz, Nese, Schiffer, Celia A, Matsuo, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698744/ https://www.ncbi.nlm.nih.gov/pubmed/31424549 http://dx.doi.org/10.1093/nar/gkz550

Ejemplares similares

Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s
por: Hou, Shurong, et al.
Publicado: (2021)

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions
por: Silvas, Tania V., et al.
Publicado: (2018)

Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA
por: Maiti, Atanu, et al.
Publicado: (2018)

Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state
por: Maiti, Atanu, et al.
Publicado: (2022)

Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease
por: Cai, Yufeng, et al.
Publicado: (2014)

Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation
por: Xiao, Xiao, et al.
Publicado: (2017)

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity
por: Kouno, Takahide, et al.
Publicado: (2017)

The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity
por: Wolfe, Aaron D, et al.
Publicado: (2020)

NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate
por: Harjes, Stefan, et al.
Publicado: (2017)

Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding
por: Miętus, Michał, et al.
Publicado: (2014)

Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi
por: Li, Wenjing, et al.
Publicado: (2015)

Structural basis for the substrate specificity and catalytic features of pseudouridine kinase from Arabidopsis thaliana
por: Kim, Sang-Hoon, et al.
Publicado: (2020)

Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae
por: Moon, Andrea F., et al.
Publicado: (2011)

Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G
por: Kouno, Takahide, et al.
Publicado: (2015)

Viral proteases: Structure, mechanism and inhibition
por: Zephyr, Jacqueto, et al.
Publicado: (2021)

X-ray structure of the fourth type of archaeal tRNA splicing endonuclease: insights into the evolution of a novel three-unit composition and a unique loop involved in broad substrate specificity
por: Hirata, Akira, et al.
Publicado: (2012)

FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis
por: Waters, Catherine E., et al.
Publicado: (2014)

Exclusion of small terminase mediated DNA threading models for genome packaging in bacteriophage T4
por: Gao, Song, et al.
Publicado: (2016)

Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation
por: Xiao, Xiao, et al.
Publicado: (2017)

Interdependence of Inhibitor Recognition in HIV-1 Protease
por: Paulsen, Janet L., et al.
Publicado: (2017)

Structural dissection of sequence recognition and catalytic mechanism of human LINE-1 endonuclease
por: Miller, Ian, et al.
Publicado: (2021)

Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps
por: Sato, Hideaki, et al.
Publicado: (2021)

Exploring APOBEC3A and APOBEC3B substrate specificity and their role in HPV positive head and neck cancer
por: Papini, Christina, et al.
Publicado: (2022)

Diverse substrate recognition and hydrolysis mechanisms of human NUDT5
por: Arimori, Takao, et al.
Publicado: (2011)

Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase
por: Nowacka, Marzena, et al.
Publicado: (2021)

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex
por: Möckel, Carolin, et al.
Publicado: (2012)

Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing
por: Liu, Nan, et al.
Publicado: (2020)

Crystal structure of RuvC resolvase in complex with Holliday junction substrate
por: Górecka, Karolina M., et al.
Publicado: (2013)

Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase
por: Ito, Kosuke, et al.
Publicado: (2012)

Substrate specificities of Escherichia coli ItaT that acetylates aminoacyl-tRNAs
por: Zhang, Chuqiao, et al.
Publicado: (2020)

Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation
por: Abula, Abudureyimu, et al.
Publicado: (2021)

HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA
por: Morse, Michael, et al.
Publicado: (2019)

Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNA
por: Kim, Nak-Kyoon, et al.
Publicado: (2010)

The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions
por: Kaustov, Lilia, et al.
Publicado: (2019)

An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening
por: Xiang, Manli, et al.
Publicado: (2023)

Genome scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes
por: Cai, Erica P., et al.
Publicado: (2020)

Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors
por: Matthew, Ashley N., et al.
Publicado: (2020)

Structure-Based Design of First-Generation Small Molecule Inhibitors Targeting the Catalytic Pockets of AID, APOBEC3A, and APOBEC3B
por: King, Justin J., et al.
Publicado: (2021)

A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner
por: Gowravaram, Manjeera, et al.
Publicado: (2018)

Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates
por: Ditzler, Mark A., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_018casa3pc5hjeu0mf82aiqfdu