TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrity

The multifunctional human DNA2 (hDNA2) nuclease/helicase is required to process DNA ends for homology-directed recombination repair (HDR) and to counteract replication stress. To participate in these processes, hDNA2 must localize to the nucleus and be recruited to the replication or repair sites. H...

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Detalles Bibliográficos
Autores principales: Meng, Yuan, Liu, Changwei, Shen, Lei, Zhou, Mian, Liu, Wenpeng, Kowolik, Claudia, Campbell, Judith L, Zheng, Li, Shen, Binghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698806/
https://www.ncbi.nlm.nih.gov/pubmed/31216032
http://dx.doi.org/10.1093/nar/gkz537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698806/
https://www.ncbi.nlm.nih.gov/pubmed/31216032
http://dx.doi.org/10.1093/nar/gkz537

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