Cargando…
Integrative construction of regulatory region networks in 127 human reference epigenomes by matrix factorization
Despite large experimental and computational efforts aiming to dissect the mechanisms underlying disease risk, mapping cis-regulatory elements to target genes remains a challenge. Here, we introduce a matrix factorization framework to integrate physical and functional interaction data of genomic seg...
Autores principales: | Liu, Dianbo, Davila-Velderrain, Jose, Zhang, Zhizhuo, Kellis, Manolis |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698807/ https://www.ncbi.nlm.nih.gov/pubmed/31265076 http://dx.doi.org/10.1093/nar/gkz538 |
Ejemplares similares
-
Regulatory genomic circuitry of human disease loci by integrative epigenomics
por: Boix, Carles A., et al.
Publicado: (2021) -
A multiresolution framework to characterize single-cell state landscapes
por: Mohammadi, Shahin, et al.
Publicado: (2020) -
Universal attenuators and their interactions with feedback loops in gene regulatory networks
por: Liu, Dianbo, et al.
Publicado: (2017) -
Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble
por: Marco, Asaf, et al.
Publicado: (2020) -
Automatic identification of informative regions with epigenomic changes associated to hematopoiesis
por: Carrillo-de-Santa-Pau, Enrique, et al.
Publicado: (2017)