A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody–Drug Conjugates

Despite tremendous efforts in the field of targeted cancer therapy with antibody–drug conjugates (ADCs), attrition rates have been high. Historically, the priority in ADC development has been the selection of target, antibody, and toxin, with little focus on the nature of the linker. We show here th...

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Detalles Bibliográficos
Autores principales: Verkade, Jorge M. M., Wijdeven, Marloes A., van Geel, Remon, Janssen, Brian M. G., van Berkel, Sander S., van Delft, Floris L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698870/
https://www.ncbi.nlm.nih.gov/pubmed/31544864
http://dx.doi.org/10.3390/antib7010012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698870/
https://www.ncbi.nlm.nih.gov/pubmed/31544864
http://dx.doi.org/10.3390/antib7010012

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