Systematic LC/MS/MS Investigations for the IND-Enabling Extended Characterization of Antibody–Drug Conjugate Modifications

We hypothesized that systematic liquid chromatography-tandem mass spectrometry investigations of an antibody–drug conjugate (ADC), its small and large molecular components, and surrogate small-molecule conjugates might comprise a simple and efficient approach for the extended characterization of ADC...

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Detalles Bibliográficos
Autores principales: Linz, Thomas, Yeo, Dominick, Hong, Qiuting, Zmolek, Wesley, McFarland, Jesse, Barfield, Robyn M., Haskins, William E., Rabuka, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698958/
https://www.ncbi.nlm.nih.gov/pubmed/31544890
http://dx.doi.org/10.3390/antib7040040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698958/
https://www.ncbi.nlm.nih.gov/pubmed/31544890
http://dx.doi.org/10.3390/antib7040040

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