Cargando…
First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells
BACKGROUND: ACAM2000, a thymidine kinase (TK)-positive strain of vaccinia virus, is the current smallpox vaccine in the US. Preclinical testing demonstrated potent oncolytic activity of ACAM2000 against several tumor types. This Phase I clinical trial of ACAM2000 delivered by autologous adipose stro...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699108/ https://www.ncbi.nlm.nih.gov/pubmed/31426803 http://dx.doi.org/10.1186/s12967-019-2011-3 |