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Polysomes identified by live imaging of nascent peptides are stalled in hippocampal and cortical neurites

In neurons, mRNAs can be repressed postinitiation and assembled into granules enabling the transport and later, regulated reactivation of the paused mRNAs. It has been suggested that a large percentage of transcripts in neuronal processes are stored in these stalled polysomes. Given this, it is pred...

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Detalles Bibliográficos
Autores principales: Langille, Jesse J., Ginzberg, Keren, Sossin, Wayne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699411/
https://www.ncbi.nlm.nih.gov/pubmed/31416908
http://dx.doi.org/10.1101/lm.049965.119