TET-Catalyzed 5-Carboxylcytosine Promotes CTCF Binding to Suboptimal Sequences Genome-wide

The mechanisms supporting dynamic regulation of CTCF-binding sites remain poorly understood. Here we describe the TET-catalyzed 5-methylcytosine derivative, 5-carboxylcytosine (5caC), as a factor driving new CTCF binding within genomic DNA. Through a combination of in vivo and in vitro approaches, w...

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Detalles Bibliográficos
Autores principales: Nanan, Kyster K., Sturgill, David M., Prigge, Maria F., Thenoz, Morgan, Dillman, Allissa A., Mandler, Mariana D., Oberdoerffer, Shalini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699469/
https://www.ncbi.nlm.nih.gov/pubmed/31404833
http://dx.doi.org/10.1016/j.isci.2019.07.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699469/
https://www.ncbi.nlm.nih.gov/pubmed/31404833
http://dx.doi.org/10.1016/j.isci.2019.07.041

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