Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies

Proteins associated with familial neurodegenerative disease often aggregate in patients’ neurons. Several such proteins, e.g. TDP-43, aggregate and are toxic when expressed in yeast. Deletion of the ATXN2 ortholog, PBP1, reduces yeast TDP-43 toxicity, which led to identification of ATXN2 as an amyot...

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Detalles Bibliográficos
Autores principales: Park, Sangeun, Park, Sei-Kyoung, Watanabe, Naruaki, Hashimoto, Tadafumi, Iwatsubo, Takeshi, Shelkovnikova, Tatyana A., Liebman, Susan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699716/
https://www.ncbi.nlm.nih.gov/pubmed/31390360
http://dx.doi.org/10.1371/journal.pgen.1008308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699716/
https://www.ncbi.nlm.nih.gov/pubmed/31390360
http://dx.doi.org/10.1371/journal.pgen.1008308

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