Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons

Abnormal subthalamic nucleus (STN) activity is linked to impaired movement in Parkinson’s disease (PD). The autonomous firing of STN neurons, which contributes to their tonic excitation of the extrastriatal basal ganglia and shapes their integration of synaptic input, is downregulated in PD models....

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Detalles Bibliográficos
Autores principales: McIver, Eileen L., Atherton, Jeremy F., Chu, Hong-Yuan, Cosgrove, Kathleen E., Kondapalli, Jyothisri, Wokosin, David, Surmeier, D. James, Bevan, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699776/
https://www.ncbi.nlm.nih.gov/pubmed/31340159
http://dx.doi.org/10.1016/j.celrep.2019.06.076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699776/
https://www.ncbi.nlm.nih.gov/pubmed/31340159
http://dx.doi.org/10.1016/j.celrep.2019.06.076

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