X chromosome inactivation does not necessarily determine the severity of the phenotype in Rett syndrome patients

Rett syndrome (RTT) is a severe neurological disorder usually caused by mutations in the MECP2 gene. Since the MECP2 gene is located on the X chromosome, X chromosome inactivation (XCI) could play a role in the wide range of phenotypic variation of RTT patients; however, classical methylation-based...

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Detalles Bibliográficos
Autores principales: Xiol, Clara, Vidal, Silvia, Pascual-Alonso, Ainhoa, Blasco, Laura, Brandi, Núria, Pacheco, Paola, Gerotina, Edgar, O’Callaghan, Mar, Pineda, Mercè, Armstrong, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700087/
https://www.ncbi.nlm.nih.gov/pubmed/31427717
http://dx.doi.org/10.1038/s41598-019-48385-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700087/
https://www.ncbi.nlm.nih.gov/pubmed/31427717
http://dx.doi.org/10.1038/s41598-019-48385-w

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