Cargando…
IP(3) receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer
Contact sites of endoplasmic reticulum (ER) and mitochondria locally convey calcium signals between the IP(3) receptors (IP3R) and the mitochondrial calcium uniporter, and are central to cell survival. It remains unclear whether IP3Rs also have a structural role in contact formation and whether the...
Autores principales: | Bartok, Adam, Weaver, David, Golenár, Tünde, Nichtova, Zuzana, Katona, Máté, Bánsághi, Száva, Alzayady, Kamil J., Thomas, V. Kaye, Ando, Hideaki, Mikoshiba, Katsuhiko, Joseph, Suresh K., Yule, David I., Csordás, György, Hajnóczky, György |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700175/ https://www.ncbi.nlm.nih.gov/pubmed/31427578 http://dx.doi.org/10.1038/s41467-019-11646-3 |
Ejemplares similares
-
Capture at the ER-mitochondrial contacts licenses IP(3) receptors to stimulate local Ca(2+) transfer and oxidative metabolism
por: Katona, Máté, et al.
Publicado: (2022) -
Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca(2+) Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU
por: Paillard, Melanie, et al.
Publicado: (2017) -
Structural and functional features and significance of the physical linkage between ER and mitochondria
por: Csordás, György, et al.
Publicado: (2006) -
Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling
por: Roy Chowdhury, Anindya, et al.
Publicado: (2020) -
MCUR1 is an Essential Component of Mitochondrial Ca(2+) Uptake that Regulates Cellular Metabolism
por: Mallilankaraman, Karthik, et al.
Publicado: (2012)