Crystal Structure of Refolding Fusion Core of Lassa Virus GP2 and Design of Lassa Virus Fusion Inhibitors

The envelope glycoproteins GP1 and GP2 of Lassa virus (LASV) bind to the host cell receptors to mediate viral infection. So far, no approved vaccines and specific treatment options against LASV exist. To develop specific fusion inhibitors against LASV, we solved the crystal structure of the post-fus...

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Detalles Bibliográficos
Autores principales: Zhang, Xuejiao, Wang, Cong, Chen, Baohua, Wang, Qian, Xu, Wei, Ye, Sheng, Jiang, Shibo, Zhu, Yun, Zhang, Rongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700223/
https://www.ncbi.nlm.nih.gov/pubmed/31456769
http://dx.doi.org/10.3389/fmicb.2019.01829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700223/
https://www.ncbi.nlm.nih.gov/pubmed/31456769
http://dx.doi.org/10.3389/fmicb.2019.01829

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