An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source

Ultrasound-promoted N-aminomethylation of indoles can be achieved in basic medium using sodium hydride and dichloromethane (DCM) as C1 donor source. This innovative amino methylation protocol results in good to excellent yields of multifunctional indole derivatives. The procedure is also applicable...

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Autores principales: Ostacolo, Carmine, Di Sarno, Veronica, Musella, Simona, Ciaglia, Tania, Vestuto, Vincenzo, Pepe, Giacomo, Merciai, Fabrizio, Campiglia, Pietro, Gomez Monterrey, Isabel M., Bertamino, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700257/
https://www.ncbi.nlm.nih.gov/pubmed/31457005
http://dx.doi.org/10.3389/fchem.2019.00568
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author Ostacolo, Carmine
Di Sarno, Veronica
Musella, Simona
Ciaglia, Tania
Vestuto, Vincenzo
Pepe, Giacomo
Merciai, Fabrizio
Campiglia, Pietro
Gomez Monterrey, Isabel M.
Bertamino, Alessia
author_facet Ostacolo, Carmine
Di Sarno, Veronica
Musella, Simona
Ciaglia, Tania
Vestuto, Vincenzo
Pepe, Giacomo
Merciai, Fabrizio
Campiglia, Pietro
Gomez Monterrey, Isabel M.
Bertamino, Alessia
author_sort Ostacolo, Carmine
collection PubMed
description Ultrasound-promoted N-aminomethylation of indoles can be achieved in basic medium using sodium hydride and dichloromethane (DCM) as C1 donor source. This innovative amino methylation protocol results in good to excellent yields of multifunctional indole derivatives. The procedure is also applicable to other aza-heterocyclic compounds and, interestingly, affords direct access to aminomethyl-substituted aryl alcohols.
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spelling pubmed-67002572019-08-27 An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source Ostacolo, Carmine Di Sarno, Veronica Musella, Simona Ciaglia, Tania Vestuto, Vincenzo Pepe, Giacomo Merciai, Fabrizio Campiglia, Pietro Gomez Monterrey, Isabel M. Bertamino, Alessia Front Chem Chemistry Ultrasound-promoted N-aminomethylation of indoles can be achieved in basic medium using sodium hydride and dichloromethane (DCM) as C1 donor source. This innovative amino methylation protocol results in good to excellent yields of multifunctional indole derivatives. The procedure is also applicable to other aza-heterocyclic compounds and, interestingly, affords direct access to aminomethyl-substituted aryl alcohols. Frontiers Media S.A. 2019-08-13 /pmc/articles/PMC6700257/ /pubmed/31457005 http://dx.doi.org/10.3389/fchem.2019.00568 Text en Copyright © 2019 Ostacolo, Di Sarno, Musella, Ciaglia, Vestuto, Pepe, Merciai, Campiglia, Gomez Monterrey and Bertamino. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Ostacolo, Carmine
Di Sarno, Veronica
Musella, Simona
Ciaglia, Tania
Vestuto, Vincenzo
Pepe, Giacomo
Merciai, Fabrizio
Campiglia, Pietro
Gomez Monterrey, Isabel M.
Bertamino, Alessia
An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source
title An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source
title_full An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source
title_fullStr An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source
title_full_unstemmed An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source
title_short An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source
title_sort efficient approach to aromatic aminomethylation using dichloromethane as methylene source
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700257/
https://www.ncbi.nlm.nih.gov/pubmed/31457005
http://dx.doi.org/10.3389/fchem.2019.00568
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