Liquid Chromatography-Tandem Mass Spectrometry Analysis of Acetaminophen Covalent Binding to Glutathione S-Transferases

Acetaminophen (APAP)-induced hepatotoxicity is the most common cause of acute liver failure in the Western world. APAP is bioactivated to N-acetyl p-benzoquinone imine (NAPQI), a reactive metabolite, which can subsequently covalently bind to glutathione and protein thiols. In this study, we have use...

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Detalles Bibliográficos
Autores principales: Geib, Timon, Lento, Cristina, Wilson, Derek J., Sleno, Lekha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700392/
https://www.ncbi.nlm.nih.gov/pubmed/31457004
http://dx.doi.org/10.3389/fchem.2019.00558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700392/
https://www.ncbi.nlm.nih.gov/pubmed/31457004
http://dx.doi.org/10.3389/fchem.2019.00558

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