A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation

Telomere signaling and metabolic dysfunction are hallmarks of cell aging. New agents targeting these processes might provide therapeutic opportunities, including chemoprevention strategies against cancer predisposition. We report identification and characterization of a pyrazolopyrimidine compound s...

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Detalles Bibliográficos
Autores principales: Bilsland, Alan E., Liu, Yu, Turnbull, Andrew, Sumpton, David, Stevenson, Katrina, Cairney, Claire J., Boyd, Susan M., Roffey, Jon, Jenkinson, David, Keith, W. Nicol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700475/
https://www.ncbi.nlm.nih.gov/pubmed/31401411
http://dx.doi.org/10.1016/j.neo.2019.07.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700475/
https://www.ncbi.nlm.nih.gov/pubmed/31401411
http://dx.doi.org/10.1016/j.neo.2019.07.008

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