Exploratory study of the effect of one week of orally administered CNSA-001 (sepiapterin) on CNS levels of tetrahydrobiopterin, dihydrobiopterin and monoamine neurotransmitter metabolites in healthy volunteers

Tetrahydrobiopterin (BH(4)) is a cofactor for the enzymes tyrosine hydroxylase and tryptophan hydroxylase, the rate-limiting enzymes in the production of the neurotransmitters, dopamine and serotonin, respectively, in the central nervous system (CNS). Administration of BH(4) is used clinically withi...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Neil, Longo, Nicola, Levert, Keith, Hyland, Keith, Blau, Nenad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700519/
https://www.ncbi.nlm.nih.gov/pubmed/31453106
http://dx.doi.org/10.1016/j.ymgmr.2019.100500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700519/
https://www.ncbi.nlm.nih.gov/pubmed/31453106
http://dx.doi.org/10.1016/j.ymgmr.2019.100500

Ejemplares similares