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Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure
BACKGROUND: Evidence has revealed that renal impairment can affect the systemic exposure of drugs which are predominantly eliminated via the liver. The modulation of drug-metabolizing enzymes and transporters expressed in the liver and/or small intestine by diverse entities, including uremic toxins,...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Bentham Science Publishers
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700602/ https://www.ncbi.nlm.nih.gov/pubmed/30947665 http://dx.doi.org/10.2174/1389200220666190402143125 |