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A model of pulldown alignments from SssI-treated DNA improves DNA methylation prediction
BACKGROUND: Protein pulldown using Methyl-CpG binding domain (MBD) proteins followed by high-throughput sequencing is a common method to determine DNA methylation. Algorithms have been developed to estimate absolute methylation level from read coverage generated by affinity enrichment-based techniqu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700779/ https://www.ncbi.nlm.nih.gov/pubmed/31426747 http://dx.doi.org/10.1186/s12859-019-3011-2 |