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Particle-Based Simulation Reveals Macromolecular Crowding Effects on the Michaelis-Menten Mechanism

Many computational models for analyzing and predicting cell physiology rely on in vitro data collected in dilute and controlled buffer solutions. However, this can mislead models because up to 40% of the intracellular volume—depending on the organism, the physiology, and the cellular compartment—is...

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Detalles Bibliográficos
Autores principales: Weilandt, Daniel R., Hatzimanikatis, Vassily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701012/
https://www.ncbi.nlm.nih.gov/pubmed/31311624
http://dx.doi.org/10.1016/j.bpj.2019.06.017