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Localization-specific distributions of protein pI in human proteome are governed by local pH and membrane charge

BACKGROUND: Whole-proteome distributions of protein isoelectric point (pI) values in different organisms are bi- or trimodal with some variations. It was suggested that the observed multimodality of the proteome-wide pI distributions is associated with subcellular localization-specific differences i...

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Detalles Bibliográficos
Autores principales: Kurotani, Atsushi, Tokmakov, Alexander A., Sato, Ken-Ichi, Stefanov, Vasily E., Yamada, Yutaka, Sakurai, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701068/
https://www.ncbi.nlm.nih.gov/pubmed/31429701
http://dx.doi.org/10.1186/s12860-019-0221-4