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Lysophosphatidic acid receptor 1 (LPA(1)) plays critical roles in microglial activation and brain damage after transient focal cerebral ischemia
BACKGROUND: Lysophosphatidic acid receptor 1 (LPA(1)) is in the spotlight because its synthetic antagonist has been under clinical trials for lung fibrosis and psoriasis. Targeting LPA(1) might also be a therapeutic strategy for cerebral ischemia because LPA(1) triggers microglial activation, a core...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701099/ https://www.ncbi.nlm.nih.gov/pubmed/31429777 http://dx.doi.org/10.1186/s12974-019-1555-8 |