Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket

The P2X7 receptor is a trimeric ligand-gated ion channel activated by ATP. It is implicated in the cellular response to trauma/disease and considered to have significant therapeutic potential. Using chimeras and point mutants we have mapped the binding site of the P2X7R-selective antagonist AZ116453...

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Detalles Bibliográficos
Autores principales: Bin Dayel, Anfal, Evans, Richard J., Schmid, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701605/
https://www.ncbi.nlm.nih.gov/pubmed/31263019
http://dx.doi.org/10.1124/mol.119.116715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701605/
https://www.ncbi.nlm.nih.gov/pubmed/31263019
http://dx.doi.org/10.1124/mol.119.116715

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