Non-Cell Autonomous Roles for CASK in Optic Nerve Hypoplasia

PURPOSE: Heterozygous mutations in the essential X-linked gene CASK associate with optic nerve hypoplasia (ONH) and other retinal disorders in girls. CASK(+/−) heterozygous knockout mice with mosaic CASK expression exhibit ONH with a loss of retinal ganglion cells (RGCs) but no changes in retinal mo...

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Detalles Bibliográficos
Autores principales: Kerr, Alicia, Patel, Paras A., LaConte, Leslie E. W., Liang, Chen, Chen, Ching-Kang, Shah, Veeral, Fox, Michael A., Mukherjee, Konark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701874/
https://www.ncbi.nlm.nih.gov/pubmed/31425583
http://dx.doi.org/10.1167/iovs.19-27197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701874/
https://www.ncbi.nlm.nih.gov/pubmed/31425583
http://dx.doi.org/10.1167/iovs.19-27197

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