A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding

Licensing of eukaryotic origins of replication requires DNA loading of two copies of the Mcm2-7 replicative helicase to form a head-to-head double-hexamer, ensuring activated helicases depart the origin bidirectionally. To understand the formation and importance of this double-hexamer, we identified...

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Detalles Bibliográficos
Autores principales: Champasa, Kanokwan, Blank, Caitlin, Friedman, Larry J, Gelles, Jeff, Bell, Stephen P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701924/
https://www.ncbi.nlm.nih.gov/pubmed/31385807
http://dx.doi.org/10.7554/eLife.45538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701924/
https://www.ncbi.nlm.nih.gov/pubmed/31385807
http://dx.doi.org/10.7554/eLife.45538

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