The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells

Overexpression of anti-apoptotic proteins MCL1 and Bcl-xL are frequently observed in many cancers. Inhibitors targeting MCL1 are in clinical development, however numerous cancer models are intrinsically resistant to this approach. To discover mechanisms underlying resistance to MCL1 inhibition, we p...

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Detalles Bibliográficos
Autores principales: Kabir, Shaheen, Cidado, Justin, Andersen, Courtney, Dick, Cortni, Lin, Pei-Chun, Mitros, Therese, Ma, Hong, Baik, Seung Hyun, Belmonte, Matthew A, Drew, Lisa, Corn, Jacob E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701926/
https://www.ncbi.nlm.nih.gov/pubmed/31294695
http://dx.doi.org/10.7554/eLife.44288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701926/
https://www.ncbi.nlm.nih.gov/pubmed/31294695
http://dx.doi.org/10.7554/eLife.44288

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