Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel

The transient receptor potential melastatin 2 (TRPM2) channel plays a key role in redox sensation in many cell types. Channel activation requires binding of both ADP-ribose (ADPR) and Ca(2+). The recently published TRPM2 structures from Danio rerio in the ligand-free and the ADPR/Ca(2+)-bound condit...

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Detalles Bibliográficos
Autores principales: Yin, Ying, Wu, Mengyu, Hsu, Allen L., Borschel, William F., Borgnia, Mario J., Lander, Gabriel C., Lee, Seok-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702222/
https://www.ncbi.nlm.nih.gov/pubmed/31431622
http://dx.doi.org/10.1038/s41467-019-11733-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702222/
https://www.ncbi.nlm.nih.gov/pubmed/31431622
http://dx.doi.org/10.1038/s41467-019-11733-5

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