Oridonin Sensitizes Cisplatin-Induced Apoptosis via AMPK/Akt/mTOR-Dependent Autophagosome Accumulation in A549 Cells

AMPK-mediated autophagy and Akt/mTOR pathways play important roles in current cancer treatments. Oridonin (Ori), an ent-kaurane diterpenoid isolated from Isodon rubescens, exerts extensive anti-tumor potential and controversial effects on autophagy. In this study, we investigated the effect of Ori o...

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Detalles Bibliográficos
Autores principales: Yang, Huahong, Gao, Yun, Fan, Xiaoye, Liu, Xingkai, Peng, Liping, Ci, Xinxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702493/
https://www.ncbi.nlm.nih.gov/pubmed/31475112
http://dx.doi.org/10.3389/fonc.2019.00769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702493/
https://www.ncbi.nlm.nih.gov/pubmed/31475112
http://dx.doi.org/10.3389/fonc.2019.00769

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