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Oridonin Sensitizes Cisplatin-Induced Apoptosis via AMPK/Akt/mTOR-Dependent Autophagosome Accumulation in A549 Cells

AMPK-mediated autophagy and Akt/mTOR pathways play important roles in current cancer treatments. Oridonin (Ori), an ent-kaurane diterpenoid isolated from Isodon rubescens, exerts extensive anti-tumor potential and controversial effects on autophagy. In this study, we investigated the effect of Ori o...

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Detalles Bibliográficos
Autores principales:	Yang, Huahong, Gao, Yun, Fan, Xiaoye, Liu, Xingkai, Peng, Liping, Ci, Xinxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702493/ https://www.ncbi.nlm.nih.gov/pubmed/31475112 http://dx.doi.org/10.3389/fonc.2019.00769

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