Analysis of TET2 mutations in paroxysmal nocturnal hemoglobinuria (PNH)

BACKGROUND: Large clonal populations of cells bearing PIG-A mutations are the sine qua non of PNH, but the PIG-A mutation itself is insufficient for clonal expansion. The association between PNH and aplastic anemia supports the immune escape model, but not all PNH patients demonstrate a history of a...

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Detalles Bibliográficos
Autores principales: Lobry, Camille, Bains, Ashish, Zamechek, Leah B., Ibrahim, Sherif, Aifantis, Iannis, Araten, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702710/
https://www.ncbi.nlm.nih.gov/pubmed/31453016
http://dx.doi.org/10.1186/s40164-019-0142-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702710/
https://www.ncbi.nlm.nih.gov/pubmed/31453016
http://dx.doi.org/10.1186/s40164-019-0142-0

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