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Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis
BACKGROUND: Lysophosphatidic acid (LPA), generated by autotaxin (ATX), is a bioactive lipid mediator that binds to the receptors (LPA(1–6)), and serves as an important mediator in inflammation. Previous studies have demonstrated that LPA-LPA(1) cascade contributes to arthritis and skin sclerosis. In...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702724/ https://www.ncbi.nlm.nih.gov/pubmed/31429784 http://dx.doi.org/10.1186/s13075-019-1973-0 |