Design, synthesis, and preliminary biological evaluation of catalpol propionates as antiaging drugs

In this paper, catalpol propionylated analogs (CPs) were designed as drug ligands of glutathione peroxidase (GSH-Px) based on molecular docking (MD) using Surflex-Docking method. The calculated total scores (Total_score) and C log P of CPs are higher than that of catalpol, which show that the CPs ma...

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Detalles Bibliográficos
Autores principales: Dong, Chunhong, Liu, Shuanglin, Cheng, Xiaodong, Wang, Qiang, Jiang, Shiqing, Wang, Guoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702743/
https://www.ncbi.nlm.nih.gov/pubmed/31453572
http://dx.doi.org/10.1186/s13065-019-0626-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702743/
https://www.ncbi.nlm.nih.gov/pubmed/31453572
http://dx.doi.org/10.1186/s13065-019-0626-3

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