Thermoresponsive and Protease‐Cleavable Interferon‐Polypeptide Conjugates with Spatiotemporally Programmed Two‐Step Release Kinetics for Tumor Therapy

Protein‐polymer conjugates show improved pharmacokinetics but reduced bioactivity and tumor penetration as compared to native proteins, resulting in limited antitumor efficacy. To address this dilemma, genetic engineering of a body temperature‐responsive and matrix metalloproteinase (MMP)‐cleavable...

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Detalles Bibliográficos
Autores principales: Wang, Zhuoran, Guo, Jianwen, Sun, Jiawei, Liang, Ping, Wei, Yan, Deng, Xuliang, Gao, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702759/
https://www.ncbi.nlm.nih.gov/pubmed/31453069
http://dx.doi.org/10.1002/advs.201900586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702759/
https://www.ncbi.nlm.nih.gov/pubmed/31453069
http://dx.doi.org/10.1002/advs.201900586

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