Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na(+)/Cl(–) Cotransporter NCC and Transiently Affects Sodium Handling

Chronic glucocorticoid infusion impairs NCC activity and induces a non-dipping profile in mice, suggesting that glucocorticoids are essential for daily blood pressure variations. In this paper, we studied mice lacking the renal tubular glucocorticoid receptor (GR) in adulthood (GR knockouts, Nr3c1(P...

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Detalles Bibliográficos
Autores principales: Canonica, Jérémie, Frateschi, Simona, Boscardin, Emilie, Ebering, Anna, Sergi, Chloé, Jäger, Yannick, Peyrollaz, Thibaud, Mérillat, Anne-Marie, Maillard, Marc, Klusonova, Petra, Odermatt, Alex, Koesters, Robert, Debonneville, Anne, Staub, Olivier, Verouti, Sophia N., Hummler, Edith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702950/
https://www.ncbi.nlm.nih.gov/pubmed/31474871
http://dx.doi.org/10.3389/fphys.2019.00989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702950/
https://www.ncbi.nlm.nih.gov/pubmed/31474871
http://dx.doi.org/10.3389/fphys.2019.00989

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