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Molecular basis of PIP(2)-dependent regulation of the Ca(2+)-activated chloride channel TMEM16A
The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability, smooth muscle contraction, fluid secretion and gut motility. While opening of TMEM16A requires binding of intracellular Ca(2+), prolonged Ca(2+)-dependent activation results in channel dese...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704070/ https://www.ncbi.nlm.nih.gov/pubmed/31434906 http://dx.doi.org/10.1038/s41467-019-11784-8 |