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Molecular basis of PIP(2)-dependent regulation of the Ca(2+)-activated chloride channel TMEM16A

The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability, smooth muscle contraction, fluid secretion and gut motility. While opening of TMEM16A requires binding of intracellular Ca(2+), prolonged Ca(2+)-dependent activation results in channel dese...

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Detalles Bibliográficos
Autores principales: Le, Son C., Jia, Zhiguang, Chen, Jianhan, Yang, Huanghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704070/
https://www.ncbi.nlm.nih.gov/pubmed/31434906
http://dx.doi.org/10.1038/s41467-019-11784-8

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