The FLT3-ITD mutation and the expression of its downstream signaling intermediates STAT5 and Pim-1 are positively correlated with CXCR4 expression in patients with acute myeloid leukemia

Chemokine ligand 12(CXCL12) mediates signaling through chemokine receptor 4(CXCR4), which is essential for the homing and maintenance of Hematopoietic stem cells (HSCs) in the bone marrow. FLT3-ITD mutations enhance cell migration toward CXCL12, providing a drug resistance mechanism underlying the p...

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Detalles Bibliográficos
Autores principales: Cao, Tingyong, Jiang, Nenggang, Liao, Hongyan, Shuai, Xiao, Su, Jun, Zheng, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704161/
https://www.ncbi.nlm.nih.gov/pubmed/31434952
http://dx.doi.org/10.1038/s41598-019-48687-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704161/
https://www.ncbi.nlm.nih.gov/pubmed/31434952
http://dx.doi.org/10.1038/s41598-019-48687-z

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