Site-Specific Glycation and Chemo-enzymatic Antibody Sortagging for the Retargeting of rAAV6 to Inflamed Endothelium

Gene therapy holds great potential for conditions such as cardiovascular disease, including atherosclerosis and also vascular cancers, yet available vectors such as the adeno-associated virus (rAAV) transduce the vasculature poorly. To enable retargeting, a single-chain antibody (scFv) that binds to...

Descripción completa

Detalles Bibliográficos
Autores principales: Pearce, Hannah A., Qian, Hongwei, Connell, Timothy U., Huang, Dexing, Gottstein, Claudia, Donnelly, Paul S., Peter, Karlheinz, Gregorevic, Paul, Hagemeyer, Christoph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704353/
https://www.ncbi.nlm.nih.gov/pubmed/31453264
http://dx.doi.org/10.1016/j.omtm.2019.07.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704353/
https://www.ncbi.nlm.nih.gov/pubmed/31453264
http://dx.doi.org/10.1016/j.omtm.2019.07.003

Ejemplares similares