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Ouabain-regulated phosphoproteome reveals molecular mechanisms for Na(+), K(+)–ATPase control of cell adhesion, proliferation, and survival
The ion pump Na(+), K(+)–ATPase (NKA) is a receptor for the cardiotonic steroid ouabain. Subsaturating concentration of ouabain triggers intracellular calcium oscillations, stimulates cell proliferation and adhesion, and protects from apoptosis. However, it is controversial whether ouabain-bound NKA...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Federation of American Societies for Experimental Biology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704450/ https://www.ncbi.nlm.nih.gov/pubmed/31199885 http://dx.doi.org/10.1096/fj.201900445R |