Metabolomics analysis elucidates unique influences on purine / pyrimidine metabolism by xanthine oxidoreductase inhibitors in a rat model of renal ischemia-reperfusion injury

BACKGROUND: Clinically applied as anti-gout drugs, xanthine oxidoreductase (XOR) inhibitors, especially the potent, selective, non-purine-analog XOR inhibitors febuxostat and topiroxostat, exert organ-protective effects. We tested the hypothesis that preservation of tissue concentrations of high-ene...

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Detalles Bibliográficos
Autores principales: Tani, Takashi, Okamoto, Ken, Fujiwara, Megumi, Katayama, Akira, Tsuruoka, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704627/
https://www.ncbi.nlm.nih.gov/pubmed/31438839
http://dx.doi.org/10.1186/s10020-019-0109-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704627/
https://www.ncbi.nlm.nih.gov/pubmed/31438839
http://dx.doi.org/10.1186/s10020-019-0109-y

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