Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47(phox) phosphorylation, NADPH oxidase activation and MuRF1 expression

BACKGROUND: Spaceflight or microgravity conditions cause myocardial atrophy and dysfunction, contributing to post-flight orthostatic intolerance. However, the underlying mechanisms remain incompletely understood and preventive approaches are limited. This study investigated whether and how losartan,...

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Detalles Bibliográficos
Autores principales: Liang, Liwen, Yuan, Wenyi, Qu, Lina, Li, Huili, Zhang, Lulu, Fan, Guo-Chang, Peng, Tianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704685/
https://www.ncbi.nlm.nih.gov/pubmed/31438970
http://dx.doi.org/10.1186/s12967-019-2021-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704685/
https://www.ncbi.nlm.nih.gov/pubmed/31438970
http://dx.doi.org/10.1186/s12967-019-2021-1

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