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Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by PARP-1 inhibition in non-small-cell lung cancer
BACKGROUND: Carbon ion ((12)C) radiotherapy is becoming very promising to kill highly metastatic cancer cells keeping adjacent normal cells least affected. Our previous study shows that combined PARP-1 inhibition with (12)C ion reduces MMP-2,-9 synergistically in HeLa cells but detailed mechanism ar...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704719/ https://www.ncbi.nlm.nih.gov/pubmed/31438892 http://dx.doi.org/10.1186/s12885-019-6015-4 |