Proprotein convertase subtilisin/kexin type 9 (PCSK9) in Alzheimer’s disease: A genetic and proteomic multi-cohort study

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a hepatic enzyme that regulates circulating low-density lipoprotein (LDL) cholesterol levels by binding to LDL receptors (LDLR) and promoting their degradation. Although PCSK9 inhibitors were shown to reduce the risk of cardiovascu...

Descripción completa

Detalles Bibliográficos
Autores principales: Picard, Cynthia, Poirier, Alexandre, Bélanger, Stéphanie, Labonté, Anne, Auld, Daniel, Poirier, Judes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705826/
https://www.ncbi.nlm.nih.gov/pubmed/31437157
http://dx.doi.org/10.1371/journal.pone.0220254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705826/
https://www.ncbi.nlm.nih.gov/pubmed/31437157
http://dx.doi.org/10.1371/journal.pone.0220254

Ejemplares similares