Proprotein convertase subtilisin/kexin type 9 (PCSK9) in Alzheimer’s disease: A genetic and proteomic multi-cohort study

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a hepatic enzyme that regulates circulating low-density lipoprotein (LDL) cholesterol levels by binding to LDL receptors (LDLR) and promoting their degradation. Although PCSK9 inhibitors were shown to reduce the risk of cardiovascu...

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Detalles Bibliográficos
Autores principales: Picard, Cynthia, Poirier, Alexandre, Bélanger, Stéphanie, Labonté, Anne, Auld, Daniel, Poirier, Judes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705826/
https://www.ncbi.nlm.nih.gov/pubmed/31437157
http://dx.doi.org/10.1371/journal.pone.0220254

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